KMID : 1129720130300040281
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Korean Journal of Acupuncture 2013 Volume.30 No. 4 p.281 ~ p.288
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The Effect of Stephaniae tetrandrae Radix Herbal-acupuncture at KI10 on LPS Induced Nephritis in Rats
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±è±âÃá:Kim Ki-Choon
ÀÓÀ±°æ:Yim Yun-Kyoung
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Abstract
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Objectives : This study aimed to evaluate the effects of Stephaniae tetrandrae Radix Herbal-acupuncture(SR-HA) at KI10(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats.
Methods : Male SD rats (n=32) were allocated to four groups; normal, LPS, saline, and SR-HA. The rats in the LPS, saline, and SR-HA groups were injected intra-peritoneally with LPS (2 mg/kg) to induce nephritis. The rats in the saline and SR-HA groups were treated with saline injection and SR-HA respectively at KI10 three times a week. To evaluate the effects of SR-HA at KI10 on nephritis in rats, the authors evaluated the numbers of WBC and neutrophils in blood, and the levels of creatinine, TNF-¥á, CINC-1 in serum, creatinine, total protein in urine and renal MPO.
Results : SR-HA at KI10 significantly inhibited the increase of WBC and neutrophils in blood, TNF-¥á, CINC-1 in serum, creatine, total protein in urine and MPO in kidney of LPS-stimulated rats.
Conclusions : SR-HA at KI10 may have therapeutic effects on nephritis in LPS-stimulated rats.
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KEYWORD
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nephritis, herbal-acupuncture, KI10, Stephaniae tetrandrae Radix, LPS
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